In Vitro Examination of Degenerative Evolution of Adrenergic Nerve Endings in Pulmonary Inflamatory Processes in Newborns

Morphological aspect of tracheal preparations and pulmonary tissue was studied in vitro. Th e material was obtained from autopsy of newborns that died from diff erent causes. Examinations were made in different gestational periods (immature - weeks; premature - weeks; mature > weeks). Material for examination was obtained up to  hours after death. Pulmonary and tracheal tissue was incubated for fi xation in buff ered formalin (). Special histochemical and histoenzymatic methods were used for coloring of pulmonary and tracheal tissue and the activity of ATP-ase and dopaoxidase was monitored. Cut out models were made in series of μ,  μ and  μ. In peripheral axons of tracheobronchial pathways, degenerative alterations of adrenergic nerve endings in lung infl ammatory processes were documented. Th ese morphologic neuronal changes were described: Walerians degeneration, neuro-axonal degeneration and segment demyelinisation. Th ese changes are well seen with argentafi ne coloring (Sevier-Munger modifi cation for nerve endings) and with dopaoxidase reaction. In mature newborns that died from respiratory distress syndrome, we found diff erent forms of metabolic and toxic degenerative damage in peripheral axons, such as: segment demyelinisation, neurotubular fragmentation, Schwan cell proliferaIN VITRO EXAMINATION OF DEGENERATIVE EVOLUTION OF ADRENERGIC NERVE ENDINGS IN PULMONARY INFLAMATORY PROCESSES IN NEWBORNS Hilmi Islami 1*, Ragip Shabani2, Naim Haliti3, Sadi Bexheti6, Rozafa Koliqi4, Denis Raka4, Aziz Sukalo5, Rusmi Izairi4, Hilmi Dauti6, Nazim Qehaja2 1 Department of Pharmacology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. , Pristhina, Kosovo 2 Department of Patology, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. , Pristhina, Kosovo 3 Department of Forensic Medicine, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. , Pristhina, Kosovo 4 Department of Pharmacy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. , Pristhina, Kosovo 5 Drugs factory-Bosnalijek -Sarajevo, Bosnalijek dd, Jukićeva ,  Sarajevo, Bosnia and Herzegovina 6 Department of Anatomy, Faculty of Medicine, University of Prishtina, Clinical Centre N.N. , Pristhina, Kosovo * Corresponding author